Fig. 3

Cholangiocyte differentiation was dependent on the production rates. Diff was shown in the color scale for varying Delta or Notch production (\(\beta _{D}\) or \(\beta _{N}\)). The four panels were prepared for indicated conditions for the feedback strength (m) and Hill coefficient (n). In all panels, some conditions in Delta or Notch production (\(\beta _{D}\) or \(\beta _{N}\)) showed no cholangiocyte differentiation (shown in blue) even in the presence of a PV cell, suggesting that cholangiocyte differentiation is dependent on the production rates of Delta ligands and Notch receptors.