Figure 2

Multiple sequence alignment of SH2 domains of Shp-1 and Shp-2 for analysis of PY pocket residues. SH2 domain alignment show conserved PY pockets, such as "FLVRES" in C-sh2 and "FLARPS" in N-sh2 domains of both Shp-1 and Shp-2. Percentage of sequence identity, conservation of residues in PY pockets as well as sh2 domains are shown as change in color intensity. PY pocket is found to be highly conserved in N-sh2 domains, in comparison to C-sh2 domains.