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Table 2 KCN inhibition of rate of peroxidation of unbound UCB by HRP (Kp)

From: Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver

Relative Kpa

 

vs control

vs LMbor BMc

Control (n = 18)

100 ± 3.1

 

0.5 mM KCN (n = 12)

84.7 ± 5.8 (p < 0.001)

 

1.0 mM KCN (n = 11)

73.4 ± 5.8 (p < 0.001)

 

BMb(n = 11)

99.2 ± 4.4 (p = 0.618)

 

0.5 mM KCN (n = 6)

88.7 ± 3.3 (p < 0.001)

89.4 ± 3.4 (p < 0.001)

1.0 mM KCN (n = 6)

72.1 ± 6.8 (p < 0.001)

72.1 ± 6.9 (p < 0.001)

LMc(n = 12)

172 ± 6.2 (p < 0.001)

 

0.5 mM KCN (n = 6)

102 ± 8.1 (p = 0.580)

59.4 ± 4.7 (p < 0.001)

1.0 mM KCN (n = 6)

83.8 ± 9.3 (p < 0.001)

48.8 ± 5.4 (p < 0.001)

  1. aPercent of Kp values normalized to control (no mitochondria); bBM, mouse brain mitochondria; cLM, mouse liver mitochondria.
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BMC Research Notes

ISSN: 1756-0500

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