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Table 1 Systematic reviews on moxibustion for health care

From: Does moxibustion work? An overview of systematic reviews

First author

Year (Ref)

Condition

No. of primary studies

Methodological quality of primary studies†

Quality of SR

OQAQ*

Meta-analysis

Conclusion (quote)†

Authors' result†

Kim

(2010) [3]

Various conditions

48 RCTs

Poor

5

Ulcerative colitis

1) Moxa vs. drug (2 RCTs), RR, 2.20, 95% CIs,1.37 to 3.52, P = 0.001, I2 = 0%

2) Moxa vs. wait control (2 RCTs), RR, 1.19, 95CIs, 0.88 to 1.60, P = 0.26, I2 = 40%

3) Moxa plus postual care vs. postual care, RR, 1.51, 95%CIs, 1.10 to 2.08, P = 0.01, I2 = 86%

Our results did not support the effectiveness of moxibustion in specific disease

+/-

Coyle

(2005) [7]

Breech presentation

3 RCTs

Poor

7

None

There is insufficient evidence to support ...

+/-

Li

(2009) [8]

Breech presentation

17(10 RCTs and 7 CCTs)

Poor

7

1) Moxa vs. no treatment (3 RCTs), RR, 135, 95%CIs, 1.20 to 1.51, P < 0.00001

2) Moxa vs. knee-chest position (3 RCTs), RR, 1.30, 95%CIs, 0.95 to 1.79, P = 0.1

3) Moxa plus other treatment vs. other treatment (2 RCTs), RR, 1.36, 95%CIs, 1.21 to 1.54, P < 0.00001

...tend to be effective...

+

Vas

(2009) [9]

Breech presentation

7 RCTs

Variable

7

Moxa vs. control (6 studies), RR, 1.36, 95% CIs, 1.17 to 1.58, P < 0.0001

Moxibustion at ...BL67 has been shown to produce a positive effect...

+

Lee

(2010) [10]

Ulcerative colitis

5 RCTs

Poor

7

Moxa vs. drug (5 RCTs), RR, 1.24, 95% CIs, 1.11 to 1.38, P < 0.0001, I2 = 16%

Current evidence is insufficient ...

+/-

Lee

(2010) [11]

Cancer

5 RCTs

Poor

6

Moxa plus chemotherapy vs. chemotherapy

1) Response rate (4 RCTs), RR, 1.04, 95% CIs, 0.94 to 1.15, P = 0.43, I2 = 26%

2) Side effects (2 RCTs), RR, 0.38, 95% CIs, 0.22 to 0.65, P = 0.0005, I2 = 0%

The evidence is limited to suggest moxibustion is an effective supportive cancer care in nausea and vomiting.

+

Lee

(2010) [12]

Stroke rehabilitation

9 RCTs

Poor

5

Moxa vs. standard care

1) Motor function (3RCTs), SMD, 0.72, 95% CIs, 0.37 to 1.08, P < 0.0001, I2 = 5%

2) Activities of daily living (3 RCTs), SMD, 0.51, 95%CIs,

-0.08 to 1.10, P = 0.09, I2 = 62%

...found limited effectiveness of moxibustion as an adjunct to standard care...

+

Lee

(2010) [13]

Pain conditions

4 RCTs

Poor

7

Osteoarthritis: Moxa vs. drug (2 RCTs), RR, 1.11, 95%CIs, 1.02 to 1.21, P = 0.02, I2 = 3%

...limited evidence ... in the management of osteoarthritis of the knee and other pain condition

+

Lee

(2010) [14]

Constipation

3 RCTs

Poor

3

None

... evidence is scarce and insufficient to suggest...

+/-

Kim

(2010) [15]

Hypertension

4 RCTs

Poor

5

None

There is insufficient...

+/-

  1. † This was relied on the original authors' judgment;* Overview quality assessment questionnaire (OQAQ). The overall score is from 1 to 7. OQAQ ≤ 3: having extensive or major flaws; 5 ≤ OQAQ: having minor or minimal flaws. +: overall positive; -: fail to show effectiveness; +/-: unclear. SR: systematic review; RCT: randomized controlled trial; CCT: non-randomized controlled trial.