Adverse symptoms/reactions | Source | Criteria |
---|---|---|
Phlebitis | Medical records | Indicated by medical personnel |
Nephrotoxicity | Medical records/Laboratorial analysis | Serum creatinine concentrations of 0.5 mg/dl or 50% increase over the baseline, whichever is the higher value14 |
Neutropenia | Medical records/Laboratorial analysis | Neutrophil count below 1,000 cells per cm3 of peripheral blood1 |
Ototoxicity | Medical records | Indicated by medical personnel after audiometric evaluations and reports of hearing loss after treatment, obtained by attending physicians in the process of anamnesis; |
Thrombocytopenia | Medical records/Laboratorial analysis | Platelet count less than 100,000 per microliter of peripheral blood |
Red man syndrome | Medical records | Indicated by attending physicians and reviewers, faced with the following standard of diagnosis: flushing, itching, chest pain, muscle spasm or hypotension during infusion of vancomycin |