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Table 1 Which of the following signs and symptoms make you suspect PID?

From: Attentiveness of pediatricians to primary immunodeficiency disorders

 

Percent answered “yes”

Persistent oral thrush

97

Infections with uncommon organisms

96

Failure of infant to thrive

90

Sepsis with atypical mycobacteria

83

Severe dermatitis

81

Two invasive deep seated infections

80

Delayed wound healing

79

Death of a sibling in infancy

77

Absent tonsils

75

Autoimmune cytopenia

65

Partial albinism

65

Lymphoma

64

Otitis media (5 bouts per year)

62

Interrupted aortic arch

62

Pneumonia (2 bouts per year)

59

Severe warts

57

Severe periodontitis

55

Polyendocrinopathy

48

Dextrocardia *

45

Transfusion reaction

44

Malar rash *

28

Inguinal lymphadenopathy *

22

Polydactaly *

20

Ventricular septal defect *

9

  1. *Does not increase likelihood of PID.
  2. (The order of the items is presented according to the percentage picked by respondents, not how it appeared in the questionnaire).