Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study

Table 3 Cross-sectional associations between oxidative stress (urinary F ₂ -Isoprostanes) and eGFR _cyst and albumin creatinine ratio (ACR) at age 77: Multivariable regression

	Cystatin c estimated glomerular filtration rate		lnAlbumin creatinine ratio (ACR)
	total cohort (n = 647)	eGFR > 60 ml/min/1.73 m² (n = 514)	total cohort (n = 647)	ACR < 3 mg/mmol (n = 522)
	β-coefficient (95% CI)	β-coefficient (95% CI)	β-coefficient (95% CI)	β-coefficient (95% CI)
Model A
ln F2-isoprostane (nmol/mmol)	0.08 (0.006 to 0.16)*	0.04 (−0.03 to 0.11)	−0.13 (−0.20 to −0.05) ***	0.004 (−0.04 to 0.05)
Model B (DAG adjusted)
ln F2-isoprostane (nmol/mmol)	0.09 (0.02 to 0.17)*	0.03 (−0.03 to 0.10)	−0.12 (−0.19 to −0.04) **	0.0008 (−0.05 to 0.05)
Model C
ln F2-isoprostane (nmol/mmol)	0.09 (0.01 to 0.16)*	0.03 (−0.04 to 0.10)	−0.12 (−0.20 to −0.05) ***	−0.001 (−0.05 to 0.05)

Data are regression coefficients for a 1-SD urinary ln F2-isoprostanes. Model A was adjusted for age; model B was adjusted according to directed acyclic graphs (DAG): age, BMI, smoking, systolic and diastolic blood pressure, LDL, HDL, and triglyceride, statin treatment, ACE inhibitor-, ASA-, anti-inflammation-, and cortisone medication. Model C was adjusted for: age, BMI, smoking, systolic and diastolic blood pressure, hypertension treatment, LDL, HDL, and triglyceride, statin treatment, diabetes, ACE inhibitor-, ASA-, anti-inflammation-, and corticosteroid treatment, and CVD. * p < 0.05, **p < 0.01. *** p < 0.001.

ISSN: 1756-0500