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Table 3 Few examples revealing differences in the expression profiles based on selection of the most abundant isomiR versus the reference miRNA

From: Analysis of the microRNA transcriptome and expression of different isomiRs in human peripheral blood mononuclear cells

3A)

miRNAs

Normal 1

Normal 2

Reference miRNA frequency

Most abundant isomiR frequency

Reference miRNA frequency

Most abundant isomiR frequency

hsa-miR-10a-5p

171

935

195

792

hsa-miR-15b-5p

2266

4355

992

2547

hsa-miR-21-5p

30955

49979

33091

50565

hsa-miR-23a-3p

11160

21009

8375

17718

hsa-miR-26b-5p

3409

28934

3685

23018

hsa-miR-30d-5p

1449

14156

1893

15233

3B)

miRNAs

Patient 1

Patient 2

Reference miRNA frequency

Most abundant isomiR frequency

Reference miRNA frequency

Most abundant isomiR frequency

hsa-miR-10a-5p

56

256

99

396

hsa-miR-15b-5p

1835

2342

1187

4114

hsa-miR-21-5p

8868

18032

36712

75907

hsa-miR-23a-3p

5793

11774

8296

16159

hsa-miR-26b-5p

2239

12346

10093

51801

hsa-miR-30d-5p

1638

8012

1619

15705

  1. A) in Normal samples. (B) in Patient samples.