Figure 3
Comparison of omeprazole and saline treated C57BL/6J mice with EAE. Average clinical scores (A) revealed no significant differences between groups, but weight differences (B) revealed that omeprazole treated EAE mice (n = 12) had significantly less weight gain relative to Day 7 than saline EAE mice (n = 12). Rotarod latency at Day 14 (C), Day 25 (D), and Day 40 (E) post-encephalitogen, with no differences observed between omeprazole and saline groups. A strong negative correlation was observed between clinical score and rotarod latency during active disease at Day 40 post-encephalitogen (r2 = -0.747, p < 0.005), but not at Day 14 or Day 25. Black squares, saline treatment; white squares, omeprazole treatment. Histological examination revealed no major differences in inflammatory cell infiltrates in the hindbrains of both saline (F) and omeprazole (G) C57BL/6J mice during active disease. Bar = 50 μm.