Figure 5From: Subtoxic levels of hydrogen peroxide induce brain-derived neurotrophic factor expression to protect PC12 cellsSchematic depiction of the present study. Oxidative stress generated by H2O2 treatment induces PC12 cell death; however, this subtoxic level of oxidative stress also induces BDNF. BDNF signals via p75NTR to protect PC12 cells, even though it inactivates the PI3K/Akt cascade that potentially induces cell survival.Back to article page