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Table 1 Characteristics of infants in the BWIS dataset

From: Mediation analysis of gestational age, congenital heart defects, and infant birth-weight

 

Group

p-value

 

Cases1 (n = 3362)

Controls (n = 3564)

 

Dependent and mediating variables

 

Birth–weight, grams: mean (SD)

3071 (729)

3353 (603)

<0.0001

Gestational age, weeks: mean (SD)

38.9 (2.7)

39.6 (2.2)

<0.0001

Covariates

 

Infant’s sex (%)

   

 male

1661 (49.41)

1812 (50.84)

0.2320

 female

1701 (50.59)

1752 (49.16)

 

Infant’s race (%)

   

 white

2175 (64.69)

2358 (66.16)

 

 African American

1057 (31.44)

1108 (31.09)

0.0274

 other

130 (3.87)

98 (2.75)

 

Mother’s age at conception (SD) years

26.72 (5.92)

26.27 (5.72)

0.0014

Previous pregnancies (%)

   

 never pregnant

1014 (30.16)

1154 (32.38)

0.0006

 one

986 (29.33)

1154 (30.72)

 

 two

661 (19.66)

709 (19.89)

 

 ≥ three

701 (20.85)

606 (17.00)

 

Maternal smoking status (%)

   

 Non smoker

2150 (63.95)

2298 (64.48)

0.3363

 1–10 cigarettes/day

535 (15.91)

565 (15.85)

 

 11–20 cigarettes/day

480 (14.28)

526 (14.76)

 

 21–39 cigarettes/day

143 (4.25)

136 (3.82)

 

 40 or more cigarettes/day

54 (1.61)

39 (1.09)

 

Mother’s education (%)

   

 6 years, or less, completion

26 (0.78)

22 (0.62)

 

 7–9 years completion

220 (6.57)

228 (6.42)

 

 10–11 years completion

358 (10.7)

405 (11.4)

0.2248

 12 years completion

1265 (37.8)

1259 (35.42)

 

 13 years, or more, completion

1478 (44.16)

1640 (46.15)

 

Pre-pregnancy diabetes (%)

   

 No

3283 (98.09)

3531 (99.35)

<0.0001

 Yes

64 (1.91)

23 (0.65)

 

Method of Delivery

   

 Vaginal

2307 (68.34)

2694 (75.42)

<0.0001

 Caesarian section

1069 (31.66)

878 (24.58)

 
  1. 1Cases included 123 with laterality and looping defects, 578 with conotruncal (outflow tract) defects, 288 with endocardial cushion (atrioventricular septal) defects), 275 with pulmonic valve stenosis, 519 with left-sided obstructive defects, 859 with ventricular septal defect, 290 with atrial septal (secundum) defect, 82 with patent arterial duct, and 347 with other cardiovascular malformations.