Fig. 1
From: ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib
Effects of tozasertib and alisertib on the viability of non-ABCG2-expressing UKF-NB-3 cells, UKF-NB-3 cells transduced with a lentiviral vector encoding for ABCG2 (UKF-NB-3ABCG2), or UKF-NB-3 cells transduced with a control vector (UKF-NB-3iG2) in the absence or presence of the ABCG2 inhibitor WK-X-34 (2.5 µM) as determined by MTT assay after 120 h of incubation. WK-X-34 (2.5 µM) alone did not affect cell viability (Additional file 1: Table S1). *P < 0.05 relative to IC50 UKF-NB-3 in the absence of WK-X-34