From: Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes
Test compound | hMC1R | hMC3R | hMC4R | hMC5R |
---|---|---|---|---|
K i (nM) | K i (nM) | K i (nM) | K i (nM) | |
LY2112688 | 165 ± 51 (3) | 74 ± 27 (3) | 0.13 ± 0.01(3) | 1713 ± 686 (3) |
PG-901 | 2700 ± 153 (3) | 11 ± 0.5 (4) | 0.08 ± 0.01 (3) | 1.7 ± 0.6 (4) |
α-MSH | 1.5 ± 0.4 (18) | 46 ± 5 (9) | 10.16 ± 3.4 (3) | 150 ± 30 (7) |
ACTH | 0.09 ± 0.01 (3) | 11.1 ± 1.5 (5) | 1.2 ± 0.2 (3) | 46 ± 9.5 (5) |