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Table 5 Contributions from studies with enrichment design to mixed and indirect estimates

From: Using the contribution matrix to evaluate complex study limitations in a network meta-analysis: a case study of bipolar maintenance pharmacotherapy review

 

Depressive episode relapse

Mania episode relapse

In favour of the drug to the right (%)

In disfavour of the drug to the right (%)

Enrichment of unknown direction (%)

In favour of the drug to the right (%)

In disfavour of the rug to the right (%)

Enrichment of unknown

direction (%)

PLB vs LIT

12.12

10.49

0.05

5.73

6.83

0.24

PLB vs VPA

5.51

0.00

4.82

3.34

0.00

4.18

PLB vs LTG

48.26

0.00

1.94

21.75

0.00

1.51

PLB vs IMP

5.80

5.20

7.43

2.97

4.76

6.03

PLB vs FLX

68.79

0.00

3.02

PLB vs LIT + IMP

17.76

0.00

5.03

13.26

0.00

3.53

PLB vs ARP

0.00

0.00

0.00

99.90

0.00

0.00

PLB vs OLZ

2.59

0.00

2.25

45.83

20.40

0.22

PLB vs QTP

40.87

0.00

2.40

33.53

0.00

1.61

PLB vs RisLAI

0.69

0.00

0.58

72.94

0.00

0.03

PLB vs PAL

0.00

0.00

0.00

100.00

0.00

0.00

  1. When patients were recruited in manic (or depressive) episodes and stabilised with drug A and then after stabilisation randomised to drug A vs drug B, then such patients were considered to have been enriched against manic (or depressive) relapses but not for depressive (or manic) relapses. Contributions of the effects from studies with enrichment design to mixed or indirect comparisons were calculated as the sum of the proportion of such patients in each direct comparison, weighted by the contribution matrix
  2. ARP aripiprazole, CBZ carbamazepine, FLX fluoxetine, IMP imipramine, LIT lithium, LTG lamotrigine, OLZ olanzapine, OXC oxcarbazepine, PAL paliperidone, PLB placebo, QTP quetiapine, RisLAI risperidone long-acting injection, VPA valproate