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Table 2 Bioactivity of purified rhGM-CSF from P. pastoris and S. cerevisiae using IEC or HIC

From: Pichia pastoris versus Saccharomyces cerevisiae: a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor

  ED50 (pg/mL) LU (units/mg) Response curve range (OD unit)
GM-CSF from P. pastoris (IEC) 84.5 11.8 × 106 0.26
GM-CSF from P. pastoris (HIC) 198.7 5.0 × 106 0.32
GM-CSF from P. pastoris (crude) 1876 0.53 × 106 0.06
GM-CSF from S. cerevisiae (IEC) 27,880 0.36 × 105 0.49
GM-CSF from S. cerevisiae (crude) 37,238 0.27 × 105 0.05