The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease

BMC Research Notes

Table 1 Minor allele frequencies of PTPN22 (rs2476601) genetic variant in IBD patients and healthy controls from Morocco

SNP ID	Subgroup	Number of alleles	MAF %	Allele test
SNP ID	Subgroup	Number of alleles	MAF %	OR [95% CI]	P-value
PTPN22 rs2476601	Controls (n = 311)	11/611	1.77
	IBD (n = 195)	10/380	2.56	1.46 [0.61–3.48]	0.38
	CD (n = 135)	5/265	1.85	1.05 [0.36–3.05]	0.93
	UC (n = 60)	5/115	4.17	2.42 [0.82–7.08]	0.09

Frequencies of the PTPN22 allele between CD patients, UC patients, and IBD patients, were not significantly different compared to healthy controls
Italic value indicates trend of association (P = 0.09)
SNP ID Single nucleotide polymorphism identifiant, IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis, OR odds ratios, PTPN22 protein tyrosine phosphatase non-receptor type 22, MAF Minor Allele Frequencies

ISSN: 1756-0500