Skip to main content

Table 2 Genetic models and genotypes distribution in patients and controls

From: The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease

Gene

SNP

Group

1/2

Genotype, N (%)

Dominant model

Genotype 11 + 12 vs. 22

Recessive model

Genotype 11 vs. 12 + 22

AA

AG

GG

OR (95% CI)

P-value

OR (95% CI)

P-value

PTPN22 rs2476601

Controls

A/G

1 (0.32)

9 (2.89)

301 (96.78)

 

IBD

1 (0.51)

8 (4.10)

186 (95.38)

1.45 [0.58–3.65]

0.42

1.59 [0.09–25.7]

0.74

CD

0 (0.00)

5 (3.70)

130 (96.30)

1.15 [0.38–3.45]

0.79

NA

NA

UC

1 (1.69)

3 (5.08)

56 (94.91)

2.15 [0.65–7.09]

0.20

5.25 [0.32–85.18]

0.24

  1. No association was seen with PTPN22 SNP under dominant model AA + AG vs. GG (11 + 12 vs. 22) or recessive AA vs. AG + GG (11 vs. 12 + 22) either for the IBD group or when dividing into CD and UC groups
  2. PTPN22 protein tyrosine phosphatase non-receptor type 22, SNP Single nucleotide polymorphism, IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis, OR odds ratios
Back to article page

BMC Research Notes

ISSN: 1756-0500

Contact us