Fig. 1

Signatures and their estimated mutational exposures for normal ASCs and COAD-US tumors. Six mutational signatures estimated from 6 Normals and 431 COAD-US tumors (72 MSI-H, 80 MSI-L, and 279 MSS). Estimated mutational signatures (left) and signature mutational exposures (right), ordered as follows: Normal, MSI-H, MSI-L and MSS. In the figures to the left, each mutation feature is represented by a rectangle with colored area proportional to the expected frequency of each nucleotide. The more unequal the 4 nucleotide frequencies, the taller the rectangle. The five columns represent positions − 2, − 1, 0, 1, 2, relative to the single-base substitution. The upper right rectangles represent the expected frequency of the two transcription strands (+/−). Each signature is named by the color of the box enclosing it. These are ordered from top to bottom: red, orange, yellow, cyan, blue, purple. To the right, each vertical bar represents a tumor, and the colors indicate the relative frequency of that mutational signature in the tumor. The order of colors from top to bottom match the order of colors on the left (red to purple)