From: Two-hybrid screening of FAM13A protein partners in lung epithelial cells
Protein | Gene | PBS | Association with lung disease | Ref. |
---|---|---|---|---|
Cilia- and flagella-associated protein 97 | CFAP97 | A | No | |
Heat shock cognate 71 kDa protein | HSPA8 | A | Involved in CFTR biogenesis and trafficking | [20] |
Regulated by corticoid in cell lysate of sputum of COPD patients | [21] | |||
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform* | PPP2R5E* | A | Genetically associated with lung cancer | [22] |
PP2A activity was strongly enhanced in NSCLC | [23] | |||
TBC1 domain family member 5 | TBC1D5 | A | Induced by smoking and ozone (murine COPD model) | [24] |
Filamin-B | FLNB | C | No | |
14-3-3 protein beta/alpha | YWHAB | C | Interact with and regulate surfactant protein A2 | [25] |
Involved in lung cancer | [26] | |||
Enhancer of mRNA-decapping protein 4 | EDC4 | C | No | |
Tyrosine-protein phosphatase non-receptor type 12 | PTPN12 | D | High expression of PTPN12 is associated with favorable survival duration in patients with NSCLC | [27] |
Histone-lysine N-methyltransferase | SETMAR | D | No | |
tRNA cytosine [34]-C(5)-methyltransferase | NSUN2 | D | No | |
Retinal dehydrogenase 1 | ALDH1A1 | D | ALDH1 is a lung tumor stem cell-associated marker | [28] |
ALDH1 expression favorable prognosis in lung adenocarcinoma | [29] | |||
Polyubiquitin-B | UBB | D | Reduced protein expression in COPD lung tissues | [30] |
Eukaryotic initiation factor 4A-I | EIF4A1 | D | No | |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform** | PPP2R5A** | E | No | |
14-3-3 protein epsilon | YWHAE | E | Upregulated in lung squamous cell carcinoma | [31] |
14-3-3 protein zeta/delta | YWHAZ | E | Identified as a metastasis enhancer gene in lung cancer | [32] |
Upregulated in lung cancer | [33] | |||
Differentially expressed in malignant bronchial epithelial cell line compared to control cell line | [34] | |||
More frequent increased expression in patients with resectable lung adenocarcinoma with an improved prognosis | [35] | |||
26S proteasome non-ATPase regulatory subunit 11 | PSMD11 | F | Differentially expressed in malignant bronchial epithelial cell line compared to control cell line | [34] |