Variables | Grave’s disease | Toxic solitary/multinodular goiter | P value |
---|---|---|---|
Number | 53 | 86 | n/a |
Mean age (years) | 35.8 + 11.1 | 43.7 + 14.6 | 0.001 |
Female (%) | 73.6 | 77.9 | 0.351 |
Presenting symptoms | |||
Dysphagia and/or hoarseness (%) | 3.8 | 3.5 | 0.633 |
Neck swelling (%) | 1.9 | 7.0 | 0.178 |
Neck tenderness (%) | 0.0 | 2.3 | 0.381 |
Weight loss (%) | 9.4 | 4.7 | 0.222 |
Tremor (%) | 13.2 | 5.8 | 0.117 |
Palpitation (%) | 7.5 | 5.8 | 0.471 |
Fatigue (%) | 7.5 | 2.3 | 0.149 |
Anxiety (%) | 5.7 | 0.0 | 0.053 |
Insomnia (%) | 0.0 | 2.3 | 0.381 |
Headache (%) | 3.8 | 1.2 | 0.324 |
Nausea and/or vomiting (%) | 1.9 | 0.0 | 0.381 |
Eye manifestations (%) | 13.2 | 15.1 | 0.481 |
Heat intolerance (%) | 1.9 | 2.3 | 0.676 |
Comorbidities | |||
Upper respiratory tract infection (%) | 9.4 | 17.4 | 0.145 |
Hypertension (%) | 5.7 | 16.3 | 0.052 |
Hyperlipidemia (%) | 3.8 | 9.3 | 0.190 |
Type II Diabetes (%) | 7.5 | 24.4 | 0.009 |
Type I diabetes (%) | 3.8 | 1.2 | 0.324 |
Anemia (%) | 9.4 | 5.8 | 0.316 |
Dermatitis (%) | 9.4 | 15.1 | 0.242 |
Ischemic heart disease (%) | 0.0 | 1.2 | 0.619 |
Stroke (%) | 0.0 | 1.3 | 0.619 |
Deep vein thrombosis and/or pulmonary embolism (%) | 0.0 | 2.3 | 0.381 |
Medications | |||
Carbimazole usage prior to the thyroid scan (%) | 28.3 | 30.2 | 0.482 |
Carbimazole usage after the thyroid scan (%) | 17.0 | 10.5 | 0.196 |
Carbimazole usage during the thyroid scan (%) | 47.2 | 20.9 | 0.001 |
Normal thyroid uptake&scan while taking carbimazole (%) | 13.2 | 15.1 | 0.481 |
Propranolol (%) | 49.1 | 27.9 | 0.010 |
Artificial eye tears (%) | 5.7 | 7.0 | 0.529 |
Laboratory data | |||
TSH (milli-international units per liter) | 0.28 + 1.1 | 0.31 + 1.4 | 0.883 |
Free T4 (pmol/L) | 26.0 + 13.2 | 20.1 + 8.9 | 0.005 |
Free T3 (pmol/L) | 14.5 + 11.7 | 9.6 + 7.5 | 0.032 |
Antithyroid peroxidase antibody (IU/mL) | 216.4 + 287.0 | 251.4 + 500.2 | 0.831 |
Antithyroglobulin antibody (IU/mL) | 503.0 + 1009.0 | 355.6 + 1131.0 | 0.723 |
Vitamin D (ng/mL) | 21.7 + 11.1 | 21.6 + 9.2 | 0.967 |
Erythrocyte sedimentation rate (ESR) (mm/hr) | 29.3 + 20.4 | 33.0 + 22.9 | 0.697 |
C-Reactive protein (CRP) (mg/L) | 8.3 + 11.3 | 9.0 + 12.0 | 0.898 |
Thyroid ultrasound | |||
Enlarged thyroid gland (%) | 32.1 | 25.6 | 0.591 |
Heterogenous (%) | 49.1 | 60.5 | 0.306 |
Hypervascular (%) | 39.6 | 40.7 | 0.976 |
Bilateral lymph node enlargement (%) | 18.9 | 30.2 | 0.297 |
Unilateral lymph node enlargement (%) | 1.9 | 0.0 | |
Multiple lymph node enlargement (%) | 15.1 | 38.4 | 0.008 |
Single lymph node enlargement (%) | 13.2 | 15.1 | |
Thyroid uptake and scan | |||
Heterogenous (%) | 3.8 | 57.0 | < 0.001 |
Homogenous (%) | 96.2 | 43.0 | |
Mean uptake (%) | 19.7 + 16.2 | 16.0 + 6.4 | 0.598 |
Biochemical diagnosis | |||
Subclinical hyperthyroidism | 22.6 | 45.3 | 0.039 |
Hyperthyroidism | 67.9 | 43.0 | |
Euthyroidism | 3.8 | 9.3 | |
T3 thyro-toxicosis | 1.9 | 1.2 | |
Hypothyroidism | 1.9 | 0.0 | |
Subclinical hypothyroidism | 1.9 | 1.2 |