Table 2 Candidate genes for differential expression
From: Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours
Gene | Cytoband | Fold-change | P value | Function |
|---|---|---|---|---|
9q genes gain vs no gain | ||||
 HAPLN1 | 5q14.3 | +5.2 | 0.000008 | ECM protein and ERK signalling; overexpressed in metastatic melanoma and mesotheliomas |
 PRAME | 22q11.22 | +3.6 | 0.000342 | Repressor of retinoic acid receptor. Overexpressed in multiple neoplasms (including melanoma) |
 SLC17A3 | 6p22.2 | +3.3 | 0.000081 | Voltage-driven transporter. Affects serum uric acid levels |
 CKS2 | 9q22.2 | +3.3 | 0.000232 | CDC28 protein kinase regulatory subunit 2. Overexpressed in numerous neoplasms, overrides the intra-S-phase DNA damage checkpoint |
 ANOS1 | Xp22.31 | +2.8 | 0.000297 | ECM protein. Putative cell adhesion molecule, upregulated in some tumour types |
 RNF182 | 6p23 | +2.5 | 0.000110 | E3 ubiquitin ligase. Overexpressed in Alzheimers |
 SLC17A1 | 6p22.2 | +2.3 | 0.000711 | Sodium-dependent phosphate transporter. Affects uric acid levels |
 CRB1 | 1q31.3 | +2.1 | 0.000466 | Photoreceptor protein |
 SYT14 | 1q32.2 | +2.1 | 0.000601 | Family of proteins involved in synaptic transmission |
 C6orf115 | 6q24.1 | +2 | 0.000848 | Uncharacterised protein |
 APOD | 3q29 | −2.6 | 0.000762 | Putative lipoprotein metabolism. Inverse correlation between expression and colorectal tumour progression. Associated with neurodegeneration |
 CLU | 8p21.1 | −2.4 | 0.000751 | Secreted anti-apoptotic chaperone protein. Overexpressed in many tumour types and associated with neurodegeneration |
 SLFN11 | 17q12 | −2.3 | 0.000237 | Putative DNA/RNA helicase. Expression of other family members inhibits growth of fibroblasts and thymoctyes. Sensitises cancer cells to DNA damaging agents |
chr12 genes gain vs no gain | ||||
 NDST3 | 4q26 | +2.9 | 0.000814 | N-deacetylase/N-sulfotransferase 3. Golgi apparatus protein, associated with schizophrenia and bipolar disorder |
 PRELP | 1q32.1 | −2.2 | 0.000646 | Connective tissue ECM protein. Abnormally expressed in chronic lymphocytic leukaemia cells |
16q genes loss vs no loss | ||||
 PRAME | 22q11.22 | +6.4 | 0.000347 | Repressor of retinoic acid receptor. Overexpressed in multiple neoplasms (including melanoma). |
 GLRA2 | Xp22.2 | +2.7 | 0.000412 | Glycine receptor alpha 2, neutrophil and p38 MAPK associated |
 GABRA5 | 15q12 | +2.5 | 0.000136 | GABA receptor alpha 5, associated with schizophrenia and bipolar I disorder |
 SLFN11 | 17q12 | −3.6 | 0.000336 | Putative DNA/RNA helicase. Expression of other family members inhibits growth of fibroblasts and thymoctyes. Sensitises cancer cells to DNA damaging agents |