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Fig. 1 | BMC Research Notes

Fig. 1

From: Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer

Fig. 1

DNA methylation in key pancreatic cancer driver genes. (Left) Analyzed CpG sites in KRAS, CDKN2A, TP53 and SMAD4. Untranscribed regions (pale gray bars), exons (boxes), introns (dark gray bars) and CpGs (numbers, vertical black bars) are indicated. Arrows indicate transcriptional orientation. (Right) Averaged β-values of CpGs. Methylation levels of all CpGs in KRAS, CDKN2A, TP53 and SMAD4 were compared between high-fat diet (HFD)- (n = 7) and normal-fat diet (NFD)-mice (n = 5), with no significant changes in averaged β-values.

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BMC Research Notes

ISSN: 1756-0500

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